B-Replete®

B-Replete® by NuMedica provides the full spectrum of B vitamins in activated forms, including methylfolate (Quatrefolic®), P5P, and methylcobalamin, to support healthy methylation, neurological function, energy metabolism, and homocysteine balance.

$65.00

Quatrefolic® methylfolate bypasses MTHFR limitations for direct folate bioavailability
Activated forms (P5P, methylcobalamin, riboflavin-5-phosphate) bypass conversion requirements
Supports healthy homocysteine metabolism critical for cardiovascular and neurological health
Benfotiamine provides fat-soluble thiamine for enhanced neurological delivery

Why Catalyst Recommends This

Activated B vitamins are foundational to neurological function, supporting myelin synthesis, neurotransmitter production, homocysteine clearance, and cellular energy production. B-Replete provides the comprehensive-grade activated forms required when standard B vitamins fail due to genetic or functional conversion impairments.

Suggested Use

Take as directed with or without food. Start at lower doses in individuals with MTHFR variants or methylation sensitivity, titrating as tolerated.

Product Disclaimers

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Keep out of reach of children. Do not use if the safety seal is broken or missing. Store in a cool, dry place out of direct sunlight.

Consult with your healthcare practitioner before using this product, especially if you are pregnant, nursing, under 18 years of age, taking medications, or managing a medical condition.

This formula provides Quatrefolic® (glucosamine salt of 5-MTHF, the most bioavailable folate form), methylcobalamin (neurologically active B12), pyridoxal-5-phosphate (P5P, active B6 as a cofactor for 100+ enzymatic reactions), benfotiamine (fat-soluble thiamine for neurological delivery), riboflavin-5-phosphate (active B2 for FAD/FMN coenzyme synthesis), PABA (para-aminobenzoic acid), and therapeutic-dose niacin and pantothenic acid, all in their active, body-ready forms to support methylation, energy metabolism, and neurological cofactor needs.*

Other ingredients: Hydroxypropyl methylcellulose (vegetable capsule), microcrystalline cellulose, L-leucine, bamboo silica.

Serving Size: 1 Capsule

Total Servings: 180

Amount Per Serving		% Daily Value*
Vitamin C (as ascorbic acid)	30 mg	33%
Thiamin (as thiamin hydrochloride)	20 mg	1667%
Riboflavin (as riboflavin-5’-phosphate)	20 mg	1538%
Niacin (as 130 mg niacinamide, 10 mg niacin)	140 mg NE	875%
Vitamin B6 (as pyridoxal-5’-phosphate)	25 mg	1471%
Folate (as 400 mcg (6S)-5-methyltetrahydrofolic acid, glucosamine salt)	680 mcg DFE	170%
Vitamin B12 (as methylcobalamin)	800 mcg	33333%
Biotin	400 mcg	1333%
Pantothenic Acid (as calcium D-pantothenate)	150 mg	3000%
Choline (as choline citrate)	30 mg	5%
Benfotiamine	20 mg	**
Para-Aminobenzoic Acid (PABA)	15 mg	**