5-MTHF Plus B12

5-MTHF Plus B12 by Xymogen delivers Quatrefolic® (the most bioavailable methylfolate form) and methylcobalamin in great-tasting, cherry-flavored quick-dissolve tablets. Bypasses MTHFR enzyme limitations for direct support of methylation, homocysteine metabolism, and neurological health.

$39.00

Quatrefolic® increases plasma folate more effectively than folic acid without masking B12 deficiency
Methylcobalamin is the neurologically active, directly bioavailable form of B12
Quick-dissolve format enhances buccal absorption for faster onset
Essential for MTHFR variant carriers and individuals with methylation insufficiency

Why Catalyst Recommends This

MTHFR variants affect up to 40% of the population. 5-MTHF Plus B12 promotes efficient methylation pathway support even in individuals with impaired folate conversion, foundational for healthy neurotransmitter synthesis.

Suggested Use

Allow 1–2 tablets to dissolve under the tongue or in the mouth as directed. Cherry-flavored for patient compliance. Can be taken with or without food.

Product Disclaimers

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Keep out of reach of children. Do not use if the safety seal is broken or missing. Store in a cool, dry place out of direct sunlight.

Consult with your healthcare practitioner before using this product, especially if you are pregnant, nursing, under 18 years of age, taking medications, or managing a medical condition.

This formula provides Quatrefolic® (5-methyltetrahydrofolate glucosamine salt), the stable, patented methylfolate form that is the predominant folate metabolite in human plasma and cerebrospinal fluid, eliminating the MTHFR conversion step required by folic acid, alongside methylcobalamin (methyl-B12) as the directly bioavailable cofactor for methionine synthase, the enzyme that uses methylfolate to convert homocysteine to methionine in the one-carbon methylation cycle.*

Other ingredients: Xylitol, ascorbyl palmitate, silica, and natural cherry flavor.